Noni Scientific Research

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There is lot of research going on on Noni, morinda citrifolia,  In Chennai(India) a person named Raaman Botanical scientist is working on it, for the past 2 years, it will be unfair if i disclose all his research, but i can tell u a few things, the reports will be published within this year.  Noni, i a good nutritive fruit, with high amount of calcium and other nutrients such as vitamin c, vitamin b complex, Antoxidants, etc, It has analgesic activity, hypoglycemic action, so its a good drug for diabetes mellitus, its a good drug to protect toxicity liver.  It also possesses antimicrobial action, hence an antibiotic against, staphylococcus aerus, etc.

The following are scientific research papers submitted in various conferences:

Agomo PU, Idigo JC, Afolabi BM. "Antimalarial" medicinal plants and their impact on cell populations in various organs of mice. African Journal of Medicine and Medical Science. 1992;21(2):39-46.

Altonn H. Noni�s medical worth being tested. Honolulu, Hawaii Star-Bulletin. January 8, 2004.

Ancolio C, Azas N, Mahiou V, et al. Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome. Phytotherapy Research. 2002;16(7):646-649.

Anon: Morinda. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. October 1997.

Asuzu IU, Chineme CN. Effects of Morinda lucida leaf extract on Trypanosoma brucei brucei infection in mice. Journal of Ethnopharmacology. 1990;30(3):307-313.

Banerjee S, Johnson AD, Csiszar K, Wansley DL, McGeady P. An Extract of Morinda citrifolia Interferes with the Serum-Induced Formation of Filamentous Structures in Candida albicans and Inhibits Germination of Aspergillus nidulans. American Journal of Chinese Medicine. 2006;34(3):503-509.

Basu S, Hazra B. Evaluation of nitric oxide scavenging activity, In Vitro and Ex Vivo, of selected medicinal plants traditionally used in inflammatory diseases. Phytotherapy Research. Epublished ahead of print August 14, 2006.

Choi J, Lee KT, Choi MY, et al. Antinociceptive anti-inflammatory effect of Monotropein isolated from the root of Morinda officinalis. Biology and Pharmaceutical Bulletin. 2005;28(10):1915-1918.

Cui C, Yang M, Yao Z, Cao B, Luo Z, Xu Y, Chen Y. Antidepressant active constituents in the roots of Morinda officinalis How. [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 1995;20(1):36-39 and 62-63.

Delprete P, Cortes R. Rubiaceae of the New World. Morinda Linnaeus. New York Botanical Garden. No date given. Available at: http://www.nybg.org/bsci/res/MORINDA.HTML Accessed April 22, 2003.

Dittmar A Morinda citrifolia L.--use in indigenous Samoan Medicine Journal of Herbs, Spices, and Medicinal Plants. 1993;1(3):77-92.

Dixon AR, McMillen H, and Etkin NL. Ferment This: The Transformation of Noni, a Traditional Polynesian Medicine (Morinda citrifolia, Rubaiceae). Economics and Botany. 1999;53(1):51-68.

Etkin N, McMillen H. The ethnobotany of noni (Morinda citrifolia L., Rubiaceae): Dwelling in the land between La'au Lapa'au and testiNONIals. College of Tropical Agriculture and Human Resources Proceedings. University of Hawaii. 2003:11-16.

Ettarh RR, Emeka P. Morinda lucida extract induces endothelium-dependent and -independent relaxation of rat aorta. Fitoterapia. 2004;75(3-4):332-336.

Furusawa E, Hirazumi A, Story S, Jensen J. Antitumour [sic] potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour [sic] in mice. Phytotherapy Research. 2003;17(10):1158-1164.

HealthNotes, Inc. Noni. 2002. Available at: http://www.mycustompak.com/healthNotes/Herb/Noni.htm Accessed March 28, 2003.

Hiramatsu T, Imoto M, Koyano T, Umezawa K. Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Letters. 1993;73(2-3):161-166.

Hirazumi A, Furusawa E. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour [sic] activity. Phytotherapy Research. 1999;13(5):380-387.

Hirazumi A, Furusawa E, Chou SC, Hokama Y. Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. Proceedings of the West Pharmacology Society. 1994;37:145-146.

Hiwasa T, Arase Y, Chen Z, et al. Stimulation of ultraviolet-induced apoptosis of human fibroblast UVr-1 cells by tyrosine kinase inhibitors. FEBS Letter 1999;444(2-3):173-176.

Hornick CA, Myers A, Sadowska-Krowicka H, Anthony CT, Woltering EA. Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni). Angiogenesis. 2003;6(2):143-149.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Kamiya K, Tanaka Y, Endang H, Umar M, Satake T. Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation. Journal of Agricultural and Food Chemistry. 2004;52(19):5843-5848.

Kim IT, Park HJ, Nam JH, et al. In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis. Journal of Pharmacy and Pharmacology. 2005;57(5):607-615.

Koumaglo K, Gbeassor M, Nikabu O, de Souza C, Werner W. Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum. Planta Medica. 1992;58(6):533-534.

Li RW, Myers SP, Leach DN, Lin GD, Leach G. A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants. Journal of Ethnopharmacology. 2003;85(1):25-32.

Li YF, Gong ZH, Yang M, Zhao YM, Luo ZP. Inhibition of the oligosaccharides extracted from Morinda officinalis, a Chinese traditional herbal medicine, on the corticosterone induced apoptosis in PC12 cells. Life Sciences. 2003;72(8):933-942.

Li YF, Liu YQ, Yang M, Wang HL, Huang WC, Zhao YM, Luo ZP. The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sciences. 2004;75(13):1531-1538.

Li YF, Yuan L, Xu YK, Yang M, Zhao YM, Luo ZP. Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats. Acta Pharmacologica Sineca. 2001;22(12):1084-1088.

Liu G, Bode A, Ma WY, Sang S, Ho CT, Dong Z. Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line. Cancer Research. 2001;61(15):5749-5756.

McClatchey W. From Polynesian Healers to Health Food Stores: Changing Perspectives of Morinda citrifolia (Rubiaceae). Integrative Cancer Therapies 2002;1(2):110-120.

McKoy ML, Thomas EA, Simon OR. Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (noni). Proceedings of the West Pharmacology Society. 2002;45:76-78.

Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). European Journal of Gastroenterology and Hepatology. 2005;17(4):445-447.

Morton JF. The ocean-going noni, or Indian mulberry (Morinda citrifolia, Rubiaceae) and some of its "colorful" relatives. Economics and Botany. 1992;46 (3):241-256.

Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? American Journal of Kidney Diseases. 2000;35(2):310-312.

Qiao ZS, Wu H, Su ZW. Comparison with the pharmacological actions of Morinda officinalis, Damnacanthus officinarum and Schisandra propinqua. [Article in Chinese] Zhong Xi Yi Jie He Za Zhi. 1991;11(7):390 and 415-417.

Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part--II. Indian Journal of Physiology and Pharmacology. 1975;19(1).

Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM. Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytotherapy Research. 2002;16(7):683-685.

Samoylenko V, Zhao J, Dunbar DC, Khan IA, Rushing JW, Muhammad I. New constituents from noni (Morinda citrifolia) fruit juice. Journal of Agricultural and Food Chemistry. 2006;54(17):6398-6402.

Sang S, Cheng X, Zhu N, et al. Iridoid glycosides from the leaves of Morinda citrifolia. Journal of Natural Products. 2001;64(6):799-800.

Sang S, He K, Liu G, et al. A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L. Organic Letters. 2001;3(9):1307-1309.

Seo BI, Ku SK, Cha EM, et al. Effect of Mornidae Radix extracts on experimental osteoporosis in sciatic neurectomized mice. Phytotherapy Research. 2005;19(3):231-238.

Sittie AA, Lemmich E, Olsen CE, et al. Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida. Planta Medica. 1999;65(3):259-261.

Soon YY, Tan BK. Evaluation of the hypoglycemic and anti-oxidant activities of Morinda officinalis in streptozotocin-induced diabetic rats. Singapore Medical Journal. 2002;43(2):77-85.

Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World Journal of Gastroenterology. 2005;11(30):4758-4760.

Tona L, Cimanga RK, Mesia K, et al. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. Journal of Ethnopharmacology. 2004;93(1):27-32.

Tona L, Kambu K, Ngimbi N, Cimanga K, Vlietinck AJ. Antiamoebic and phytochemical screening of some Congolese medicinal plants. Journal of Ethnopharmacology. 1998;61(1):57-65.

Tona L, Ngimbi NP, Tsakala M, et al. Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo. Journal of Ethnopharmacology. 1999;68(1-3):193-203.

Wang M, Kikuzaki H, Csiszar K, et al. Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni). Journal of Agricultural and Food Chemistry. 1999;47:4880-4882.

Wang M, Kikuzaki H, Jin Y, et al. Novel glycosides from noni (Morinda citrifolia). Journal of Natural Products. 2000;63(8):1182-1183.

Wang MY, Su C. Cancer preventative effect of Morinda citrifolia (noni). Annals of the New York Academy of Science. 2001;952:161-168.

Wang MY, West BJ, et al. Morinda citrifolia (Noni): A literature review and recent advances in Noni research. Acta Pharmacologica Sineca. 2002 Dec;23(12):1127-1141.

West BJ, Jensen CJ, Westendorf J. Noni juice is not hepatotoxic. World Journal of Gastroenterology. 2006;12(22):3616-3619.

Wong DK. Are immune responses pivotal to cancer patient's long term survival? Two clinical case-study reports on the effects of Morinda citrifolia (Noni). Hawaii Medical Journal. 2004;63(6):182-184.

Yao H, Wu H, Feng CH, Zhao S, Liang SJ. Relation between root structure and accumulation of anthraquinones of Morinda officinalis. [Article in Chinese] Shi Yan Sheng Wu Xue Bao. 2004;37(2):96-102.

Yoshikawa M, Yamaguchi S, Nishisaka H, Yamahara J, Murakami N. Chemical constituents of Chinese natural medicine, morindae radix, the dried roots of morinda officinalis how.: structures of morindolide and morofficinaloside. Chemical and Pharmaceutical Bulletin (Tokyo). 1995;43(9):1462-1465.

Younos C, Rolland A, Fleurentin J, et al. Analgesic and behavioural [sic] effects of Morinda citrifolia. Planta Medica. 1990;56(5):430-434.

Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion. 2006;73(2-3):167-170.

Zhang ZQ, Yuan L, Yang M, Luo ZP, Zhao YM. The effect of Morinda officinalis How, a Chinese traditional medicinal plant, on the DRL 72-s schedule in rats and the forced swimming test in mice. Pharmacology, Biochemistry and Behavior. 2002;72(1-2):39-43.